Pathogenesis of cancer

FUNDAMENTALS

Statement 1: The precursor cell of the primary malignant stem cell of solid tumors is a tissue mononuclear cell (Promonocyte, Monocyte), which has genotypic and epigenetic changes.

Statement 2: The basis for the “generation” of a malignant stem cell is the return of a tissue mononuclear cell, which has genotypic and epigenetic changes, to the embryonic state during mitosis, a block of differentiation at the pluripotent or unipotent level and transformation.

Statement 3: The mechanism of “generation” of a malignant stem cell is a complex multi-stage process, when genotypic changes in a bone marrow mononuclear cell under carcinogenic influence sequentially appear, epigenetic changes in the same but tissue mononuclear cell under the influence of “super conditions” of an isolated microcavity, and mitosis is the starting point for their implementation.

Statement 4: The polymorphism of malignant cells is due to the variety of options for their “nucleation”, maturation and differentiation, as well as their own evolution and the influence of the microenvironment.

Statement 5: A malignant focus is an independent structural and functional formation that has characteristic features and conditionally repeats the structural organization and functioning of the red bone marrow.

Statement 6: The stages of formation and successive change of generations of malignant stem cells conditionally repeat the stages of formation and successive change of generations of stem cells of embryonic hematopoiesis.

Statement 7: The malignant process, as an independent system, is capable of self-organization and self-regulation; many evolutionarily determined mechanisms lie in its occurrence and development.